Société Française de Biochimie et Biologie Moléculaire

Julien Hiblot - January 2018

Max-Planck-Institute for Medical Research-Department of Chemical Biology-Heidelberg Luciferases with Tunable Emission Wavelengths. Angew Chem Int Ed Engl. 2017 Sep 22. doi: 10.1002/anie.201708277. PMID: 28941028

Hiblot J, Yu Q, Sabbadini MDB, Reymond L, Xue L, Schena A, Sallin O, Hill N, Griss R, Johnsson K.


Julien Hiblot, 31 years old, performed his studies at Lorraine University (FR) by completing a Master in Biochemistry and Molecular Biology together with a Magister in Microbiology and Enzymology. After a PhD in Structural Biology at Aix-Marseille University in the laboratories AFMB and URMITE, he continued with a postdoc at EPFL (CH) in the Laboratory of Protein Engineering (LIP). He is now senior scientist at the Max Planck Institute for Medical Research (Heidelberg, DE) in the department of Chemical Biology. His research interests are mostly focused on developing semi-synthetic biosensors for answering complex biological questions. These semi-synthetic biosensors shed light on signaling and/or metabolic pathways by allowing visualization and tracking in areas that have previously been in the dark.


Dr. Julien Hiblot 

MPI for Medical Research

Chemical Biology department

Jahnstrasse 29

D-69120 Heidelberg



We introduce luciferases whose emission maxima can be tuned to different wavelengths by chemical labeling. The luciferases are chimeras of NanoLuc with either SNAP-tag or HaloTag7. Labeling of the self-labeling tag with a fluorophore shifts the emission maximum of NanoLuc to that of the fluorophore. Luciferases with tunable colors have applications as reporter genes, for the construction of biosensors and in bioimaging.