Pauline Herviou, 26 years old, obtained an engineering degree with the specialty biotechnologies in 2018 at AgroParisTech (Paris Institute of Technology for Life, Food and Environmental Sciences). She is now performing a doctorate under the supervision of Anne Cammas and Stefania Millevoi at the Cancer Research Center of Toulouse (CRCT). Her work focuses on the function of RNA G-quadruplexes in mRNA translation. Recent transcriptome-wide studies suggested that, in cells, the equilibrium between folded and unfolded G-quadruplexes is tightly regulated. In the recent Nature communication issue, Pauline Herviou and collaborators identified the RNA binding proteins hnRNP H/F as important components of the machinery that maintains RNA G-quadruplexes in an unfolded state. Further investigation revealed their function in translational control of RNA G-quadruplex-containing mRNAs involved in the maintenance of genome integrity and in the cell response to stress. Finally, in agreement with these results, their work underscored a role for hnRNP H/F in therapy resistance in glioblastoma, one of the deadliest forms of brain cancer.