Cv

"Silvia Bottini, 33 years old, is a post-doctoral research associate at the Inserm U1065 since four years. Her research interests are focused on the characterization and the development of novel bioinformatics approaches to identify and uncover the features governing the RNA-protein interaction network both in vitro and in vivo systems. She did her PhD in Bioinformatics at the University of Siena (Italy) in the laboratory of Genomics of Novartis Vaccines Company headed by Dr. Claudio Donati, under the supervision of Dr. Alessandro Muzzi. She developed a computational pipeline, called “PIPE-chipSAD”, for bacterial transcriptome studies based on high-density microarray experiments that integrates the analysis of the hybridization signal with the genomic position of probes and identifies transcript boundaries. In October 2014, she joined Dr. Michele Trabucchi’s team at the “Centre Méditerranéen de Médecine Moléculaire” (Inserm U1065) in Nice to investigate the molecular mechanisms of regulated gene expression by miRNAs. Specifically, her works in Trabucchi’s team allowed to extend the miRNA-mediated post-transcriptional gene silencing into the nucleoplasm by demonstrating that the nucleoplasmic RNA-binding protein Sfpq controls miRNA activity in RNA-dependent fashion."