Société Française de Biochimie et Biologie Moléculaire


Offres d'emplois

Soumettre une offre

Vous trouverez ci-dessous la liste des offres d'emplois ou de stages nous ayant été soumise par nos partenaires.

La SFBBM diffuse gracieusement ces offres mais pour y répondre vous devez prendre contact directement avec les organismes concernés à partir des éléments fournis dans l'offre.

Pour soumettre une offre d'emploi vous pouvez cliquer sur le bouton soumettre une offre.

Doctoral position in molecular biology and biochemistry

CNRS

Doctoral position in molecular biology and biochemistry

Institut de Biologie Moléculaire et Cellulaire de Strasbourg, UPR Architecture et Réactivité de l’ARN

A doctoral research position is available in the research group of Franck Martin at the University of Strasbourg (ARN laboratory), Strasbourg, France. Our team is investigating the interplay between ribosomes, translation initiation factors and messenger RNAs during the translation initiation process in eukaryotes. We are especially interested in atypical translation mechanisms including Internal Ribosome Entry Site (IRES) mediated translation. In this frame, we focus our research on translation initiation of several model mRNAs such as histone H4 mRNA (Martin et al., 2011, Martin et al., 2016), viral translation during Cricket Paralysis Virus infection (Majzoub et al., 2014, Gross et al., 2017) or a pathological case of Repeat-Associated Non-AUG (RAN) translation (Tabet et al., 2018).  

The doctoral project is to set-up an innovative approach using microfluidic technology to investigate fundamental aspects of eukaryotic translation. We will use cell-free translation extracts from various organisms that will allow us to faithfully recapitulate translation in droplets. With this experimental set-up, we will be able to perform high throughput screenings that will be analysed by Next Generation Sequencing. This will be done in the frame of an on-going collaboration with the group of Michael Ryckelynck from the same department (ARN laboratory).

The research position is funded by French National Agency for Research (ANR) for 3 years starting from October 1st 2018. Salary will be adjusted according to the rules from Ecole Doctorale (ED-414) of Strasbourg.

The successful candidate will join an interdisciplinary team of molecular, cellular, and structural biologists. The project will be carried out in close collaboration with the group of Michael Ryckelynck as part of an ANR network.

Applications and informal queries about the research project and the lab should be directed by email to Franck Martin (F.Martin@ibmc-cnrs.unistra.fr). We are looking for a colleague that is highly motivated, scientifically independent and creative, and capable of contributing to a team environment. Interested applicants require a strong background in molecular biology and biochemistry. Applicants must have an excellent grasp of up-to-date molecular techniques dedicated to protein and RNA biochemistry. Applications should include a cover letter summarizing current and future research interest, a CV and contact information for at least two references.

References

 

Martin et al., 2011, Molecular Cell, doi.org/10.1016/j.molcel.2010.12.019

Martin et al., 2016, Nature Communications, doi.org/10.1038/ncomms12622

Mazjoub et al., 2014, Cell, doi.org/10.1016/j.cell.2014.10.041

Gross et al., 2017, Nucleic Acids Research, doi.org/10.1093/nar/gkx622

Tabet et al., 2018, Nature Communications, doi.org/10.1038/s41467-017-02643-5

 

Contact: Franck MARTIN (https://orcid.org/0000-0001-9724-4025)

F.Martin@ibmc-cnrs.unistra.fr

 

Lab web site: http://www-ibmc.u-strasbg.fr/spip-arn/spip.php?rubrique68

Publiée le
27.02.2018
Chargé de dossier
MARTIN Franck
Email du contact
Type de contrat
Thèse
Lieu
Strasbourg
Rémunération
A pourvoir pour
01.10.2018