Société Française de Biochimie et Biologie Moléculaire

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Post-doc position - Chromatin architecture and gene expression


The ReGArDS team (LBMC, ENS-Lyon) is looking for a post-doc to study the molecular mechanisms of gene expression in a 3-dimensional genomic context, with a special focus on RNA processing.

The project will investigate the connections between the epigenome, the 3D architecture of chromatin and the regulation of RNA processing (alternative splicing and polyadenylation) in cancer cells. The selected fellow will focus on the function of RNA helicases in this cross-talk, by integrating data obtained from high-throughput approaches and molecular and cellular biology experiments.

Recent publications

- Giraud, Terrone and Bourgeois CF (2018). Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation. BMB Rep. 51(12): 613-622.

- Lambert et al. (2018). The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation. Nucleic Acids Res. 46:7686-770.

- Bourgeois, Mortreux and Auboeuf D. (2016). The multiple functions of RNA helicases as drivers and switchers of the genetic information flow. Nature Rev. Mol. Cell Biol. 17:426-438.


The candidate must be motivated by fundamental biological questions and eager to interact with people with different backgrounds (biologists and bioinformaticians). She/he will have a strong background in molecular biology, in the field of RNA processing and/or chromatin biology. An experience in computational biology will be considered as a strong asset and candidates familiar with high-throughput technologies are warmly encouraged to apply.

The position is not funded, and the candidate will have to apply for a fellowship from french and/or international funding bodies, which will be discussed depending on the candidate's profile. As deadlines for some of these applications fall early in 2022, candidates are urged to apply as soon as possible.


The ReGArDS team, co-headed by Didier Auboeuf and Cyril Bourgeois, is internationally recognized for its expertise in molecular and computational analyses of gene expression in mammals (especially RNA splicing). It is well funded and composed of wet lab biologists and bio-informaticians, including 3 permanent scientists.

The Laboratory of Biology and Modeling of the Cell (LBMC) of ENS-Lyon hosts 15 internationally competitive teams that investigate the molecular basis of major cellular functions, using a variety of cellular and organism experimental models, and giving a strong priority to biocomputing approaches. The LBMC benefits from state-of-the-art equipement and technological facilities, either in house or on the highly dynamic research campus of Gerland, and hosts a strong bio-computing hub.

Lyon is the 2nd research and higher education center in France, and it offers a great diversity of work opportunities. It is well connected to major european cities (and beyond) by high-speed train lines and direct flight connections worldwide. Classed a UNESCO World Heritage Site, and widely considered as the french capital of gastronomy, Lyon has a rich artistic and cultural offer, but it is also a modern and dynamic city which offers a vibrant quality of life.


To apply, please send a cover letter, your CV and the names of 2-3 references to :

Cyril Bourgeois (

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