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Postdoctoral Position - RNA biology

Université d'Evry

Postdoctoral Position - RNA biology

INSERM / Université Paris Saclay, France

Applications are invited for a 2-years postdoctoral position in the field of RNA splicing in the laboratory SABNP / University of Paris Saclay, France.

The research in our group aims at better understanding the mechanism of pre-mRNA splicing in mammals by combining molecular biology, bioinformatics and cell biology. In particular, our recent findings support the possibility that liquid-liquid phase separation contribute to splice site recognition (EMBO Rep (2019)20:e47604).

The successful applicant will uncover and study novel interactions among splicing factors through bioinformatics, biochemical and functional analyses. Tacking advantage of available RNA-seq datasets, the applicant will search for functional interactions by correlation analyses. The corresponding physical interactions will be further explored using biochemical techniques and in vivo analyses of splicing. These novel interactions are of potential importance to understand cell transformation driven by splicing factors mutations.

Candidate: The ideal candidate has a French and international research experience. He/she is an ambitious and highly motivated individual with interest in RNA biology, gene expression and data processing.

Laboratory: The SABNP laboratory is part of the prestigious university Paris-Saclay. The lab focuses its research on the structure and function of RNA:Protein complexes with the aim to foster applications in medicine and biotechnology. To that end, the SABNP laboratory develops an integrative approach encompassing structural biology, bioinformatics and cell biology to enlighten the role of RNA-binding proteins related to cancer and neurodegenerative diseases.

Gross salary: 3,600 euros

Contact: For application, please provide a full CV and a cover letter.

Position open until: 05/30/2020

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Maucuer Alexandre
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Université d'Evry
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