Société Française de Biochimie et Biologie Moléculaire


Genetic code: Mechanisms, Evolution and Engineering

The genetic code was unraveled some 55 years ago, in a short period of time, but through arduous and insightful chemical and biochemical experimental designs. Formally, the genetic code is a cypher, a frozen table of correlations between two sets of letters with few variations. Viewed at the molecular level, however, the code as we know it now appeared in stages, resulting from the complex molecular recognition and selection processes full of contingencies at the core of the transition from chemistry to biology in biological evolution. In the last twenty years, a wealth of structures of active ribosomes and components of the translation apparatus has appeared. We now have a rich diversity of structures at sufficient resolution to integrate biochemical and biological observations in congruence with molecular data.

lire la suite